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Christopher Cross "Chris" Griffin is the middle child of the Griffin family . He is 13 in the first three seasons, and declared 14 in "Trading Places". He appears to have only aged a year in the course of the show in spite of Meg aging three.

In The Real Live Griffins, he is replaced by Philip Seymour Hoffman in "Fifteen Minutes of Shame".

Chris is voiced by Seth Green. However, he had not been hired until after the original Pilot Pitch. For that, series creator Seth MacFarlane provided Chris's voice, giving his voice a deeper tone as compared to how Green does it.

He played Freshman in "The Rocky Horror Simpsons Family Guy Show", he wore the same outfit in "Jungle Love". He starts his first day at school, the teacher, the cafeteria lady, the principal and the fifteen-year old Mayor Adam West are trying beat him in a "Freshman Hunt".

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